Columbus Instruments 是一家私人家族式制造商，生产用于监测实验室动物（非人类）行为和生理学的仪器以及环境研究仪器。该公司总部位于俄亥俄州哥伦布市，直接或通过一些外国私人代表在全球范围内销售其产品。Columbus Instruments 提供 70 多种产品，但最著名的是其 Oxymax 系列气体分析仪、综合实验室动物监测系统 (CLAMS)、呼吸计、活动监测仪、握力计、旋转棒和啮齿动物跑步机。
Columbus Instruments 由 Jan Czekajewski 博士创立，他设计并生产了第一台基于热稀释方法的心输出量计算机。最初设计用于与 Swanz-Ganz 导管一起使用，大公司锁定了人类市场并迫使 Columbus Instruments 进入临床前研究应用。这就是哥伦布仪器找到自己的利基和随后取得成功的地方。Columbus Instruments 很快扩展了其心输出量计算机产品线，推出了第一台用于测量啮齿动物运动活动的商用光电活动监视器，并因其设计获得了美国专利。最终，动物活动计将引领用于测量活动水平和焦虑的标准化测试，例如露天测试、明暗转换测试和探索性孔戳测试。1985 年，经过 3 年的发展，哥伦布仪器公司通过创建用于测量基础代谢的 Oxymax 间接量热仪进一步丰富了他们的产品目录。随着时间的推移，该系统被进一步完善以用于啮齿动物。今天，Oxymax 系统可以适应各种动物大小，直至牛和马 (Oxymax-XL)。
1989 年，为了应对 Exxon Valdez 石油泄漏事件，美国环保署联系了哥伦布仪器公司，以开发其 Oxymax 系统的更灵敏版本，以测量石油污染样品中微生物的呼吸作用，以帮助现场修复和清理。Micro-Oxymax 呼吸计就是这项努力的成果，并因其闭环测量方法而获得专利。2001 年，哥伦布仪器进一步开发了其 Oxymax 间接热量计，以测量其他参数，例如与能量消耗相关的食物消耗和活动水平。从那时起，Oxymax-CLAMS 不断发展，提供了除食物和活动之外的许多其他参数，并已成为制药公司和大学用于啮齿动物代谢研究的首要系统。
Columbus Instruments is a private, family-owned manufacturer of instrumentation for monitoring behavior and physiology in lab animals (non-human) as well as instrumentation for Environmental Research. The company is based in Columbus, Ohio and sells its products world-wide both directly and through a number of private foreign representatives. Columbus Instruments offers over 70 products but is most known for its Oxymax line of gas analyzers, Comprehensive Lab Animal Monitoring System (CLAMS), respirometers, activity monitors, grip strength meters, Rotarods, and rodent treadmills.
Columbus Instruments was founded by Dr. Jan Czekajewski, Ph.D., who designed and produced one of the first cardiac output computers based on the thermodilution method. Originally designed to be used with Swanz-Ganz catheters, larger companies locked up the human market and forced Columbus Instruments into pre-clinical research applications. This is where Columbus Instruments found its niche and subsequent successes. Columbus Instruments soon expanded on its line of cardiac output computers with the first commercially available photocell activity monitor for measuring locomotor activity in rodents and was awarded a US patent for its design. Eventually, the animal activity meter would lead the way for standardized tests for measuring activity levels and anxiety such as the Open Field Test, Light/Dark Transition test, and Exploratory Hole Poke test. In 1985, after 3 years of development, Columbus Instruments further diversified their catalog by creating the Oxymax Indirect Calorimeter for measuring basic metabolism. Over time the system was further refined since then for use with rodents. Today the Oxymax System can accommodate a wide range of animal sizes up to cows and horses (Oxymax-XL).
In 1989, in response to the Exxon Valdez oil spill, Columbus Instruments was contacted by the EPA to develop a more sensitive version of its Oxymax System to measure respiration of microbes in oil-contaminated samples in which to aid the research behind the site’s remediation and cleanup. The Micro-Oxymax Respirometer was the result of that effort and was awarded a patent for its Closed-Loop measurement method. In 2001 Columbus Instruments further developed its Oxymax Indirect calorimeter to also measure other parameters such as food consumption and activity levels as they relate to energy expenditure. Oxymax-CLAMS has evolved since that time to offer many additional parameters beyond food and activity and has become the premier system used by pharmaceutical companies and universities for rodent metabolism research.